Redirected Cytotoxic Effector Function

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Altered effector function of peripheral cytotoxic cells in COPD

BACKGROUND There is mounting evidence that perforin and granzymes are important mediators in the lung destruction seen in COPD. We investigated the characteristics of the three main perforin and granzyme containing peripheral cells, namely CD8+ T lymphocytes, natural killer (NK; CD56+CD3-) cells and NKT-like (CD56+CD3+) cells. METHODS Peripheral blood mononuclear cells (PBMCs) were isolated a...

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The receptors regulating natural cytotoxic effector functions.

Natural cytotoxic effector functions are regulated by a multitude of opposing signals provided by immunoglobulin and lectin-like functional molecules. While inhibitory receptors possess immunoreceptor tyrosine-based inhibition motif (ITIM) cytoplasmic sequences recruiting tyrosine phosphatases, activatory receptors require association with accesory immunoreceptor tyrosine-based activation motif...

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Cytotoxic Effector Cell Function at Different Stages of Human Monocyte- Macrophage Maturation1

Human blood-borne monocytes were cultured for up to 22 days on disposable Teflon foils. Within 8 days, these monocytes developed into mature macrophages. At various stages of differ entiation, the cells were recovered from the hydrophobic mem brane and were assayed for typical monocyte-macrophage en zymes and morphology, binding of monoclonal antibodies (OKM1, OKIal ), Fc and transferrin recept...

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Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients

BACKGROUND We have previously shown that NK (CD56+CD3-) and NKT-like (CD56+CD3+) cells are reduced in both numbers and cytotoxicity in peripheral blood. The aim of the present study was to investigate their numbers and function within induced sputum. METHODS Induced sputum cell numbers and intracellular granzyme B and perforin were analysed by flow cytometry. Immunomagnetically selected CD56+...

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Cytotoxic T lymphocyte effector function is independent of nucleus–centrosome dissociation

Cytotoxic T lymphocytes (CTLs) kill tumorigenic and virally infected cells by targeted secretion of lytic granule contents. The precise point at which secretion occurs is directed by the centrosome docking at the immunological synapse (IS). The centrosome is highly dynamic in CTLs, lagging behind the nucleus in the uropod of migrating CTLs, but translocating across the entire length of the cell...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1996

ISSN: 0021-9258

DOI: 10.1074/jbc.271.35.21214